May 13th - 14th

Broad Institute, Cambridge, MA

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2018: Outstanding Challenges

In the five years following the initial demonstrating of CRISPR-mediated genome editing, the field has grown exponentially and collectively produced a wide range of tools and methods to expand and refine the technology. Nevertheless, important challenges to the implementation of genome editing remain. This year, we explore these challenges by asking three questions: do we have all the tools we need, are we ready for therapeutic applications, and how can we make the biggest impact now?

This 2-day meeting hosted by the Zhang lab combines a peer-to-peer workshop session on the 13th with a day of talks from scientists developing and working with genome engineering tools on the 14th. Seating is limited, so please register to reserve a space.


  • Omar Abudayyeh Zhang lab @ Broad Institute

  • Marlene Belfort University of Albany

  • Maggie Bobbin Joung lab @ Harvard & MGH

  • Janice Chen Doudna lab @ UC Berkeley

  • Nicole Gaudelli Liu lab @ Broad Institute

  • Silvana Konermann Hsu lab @ Salk Institute

  • Eugene Koonin NCBI

  • Sri Kosuri UCLA

  • Zach Lippman CSHL

  • Mike Milone University of Pennsylvania

  • David Pearlman Cyrus Biotechnology

  • Wennig Qin eGenesis

  • Rotem Sorek Weizmann Institute

  • Hao Yin Wuhan University

  • Zhaolan (Joe) Zhou University of Pennsylvania


Sunday 1:00 - 6:00 Workshop

  • CRISPR DNA-targeting Basics 1:00 - 1:45

  • CRISPR Screens 1:45 - 2:15

  • CRISPR RNA-targeting Basics 2:15 - 2:45

  • Coffee 2:45 - 3:05

  • Breakout Sessions 3:05 - 3:55

  • Keynote: Eugene Koonin 4:00 - 4:30

  • Poster Session & Happy Hour 4:30 - 6:00

Monday 9:00 - 4:30 Talks

  • Session 1: Do we have all the tools we need? 9:00 - 11:30

  • Coffee 10:45 - 11:05

  • Session 2: Are we ready for therapeutic applications? 11:30 - 2:00

  • Lunch 12:20 - 1:05

  • Session 3: How can we have the biggest impact now? 2:00 - 4:30

  • Coffee 2:20 - 2:45

Learn the Basics

The workshop will kick off on Sunday afternoon with presentations from members of the Zhang lab and other experts about working with CRISPR-based tools in the lab

Get Advice

Get one-on-one advice about your experiments from experienced CRISPR users during our breakout sessions

Share your Work

Present your work during the Sunday poster session and get feedback on your work and ideas for future directions

Hear about New Advances

Monday will feature talks from leaders in the field focused on outstanding challenges in genome engineering

Can I present my work?

You are encouraged to share your work with your fellow workshop attendees. For this purpose we will have a poster session on Sunday, May 13th. Abstracts can be submitted via the registration link or email your abstract to by April 16.

Do I need to pay for anything?

Registration for the full workshop is $25 for academic attendees and $100 for industry attendess. This money helps cover the cost of meals served during the workshop. The rest of the event is made possible by the generosity of the Broad Institute and our sponsors.

Where can I stay?

We do not offer lodging, so you will need to make our own arrangements. There are several nearby hotels - two Marriotts and the Kendall Hotel. The Broad is right off the Red Line subway at the Kendall/MIT stop, so anyplace that is near the Red Line will also be convenient for getting to the meeting.